Article
Glanzmann thrombasthenia: state of the art and future directions.
Seminars in thrombosis and hemostasis - 1 Sept 2013
Nurden Alan T, Pillois Xavier, Wilcox David A
Abstract excerpt
Glanzmann thrombasthenia (GT) is the principal inherited disease of platelets and the most commonly encountered disorder of an integrin. GT is characterized by spontaneous mucocutaneous bleeding and an exaggerated response to trauma caused by platelets that fail to aggregate when stimulated by physiologic agonists. GT is caused by quantitative or qualitative deficiencies of αIIbβ3, an integrin coded by the ITGA2B...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
