Article
TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development.
The Journal of clinical investigation - 1 Jan 1999
Yin J J, Selander K, Chirgwin J M, Dallas M, Grubbs B G, Wieser R, Massagué J, Mundy G R, Guise T A
Abstract excerpt
Breast cancer frequently metastasizes to the skeleton, and the associated bone destruction is mediated by the osteoclast. Growth factors, including transforming growth factor-beta (TGF-beta), released from bone matrix by the action of osteoclasts, may foster metastatic growth. Because TGF-beta in...
Topics
- Animals
- Bone Neoplasms
- Breast Neoplasms
- Cross-Linking Reagents
- Disease Models, Animal
- Extremities
- Growth Substances
- Mice
- Mutation
- Neoplasms, Experimental
- Osteoclasts
- Parathyroid Hormone-Related Protein
- Protein Serine-Threonine Kinases
- Proteins