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Article

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development.

The Journal of clinical investigation - 1 Jan 1999

Yin J J, Selander K, Chirgwin J M, Dallas M, Grubbs B G, Wieser R, Massagué J, Mundy G R, Guise T A

Abstract excerpt

Breast cancer frequently metastasizes to the skeleton, and the associated bone destruction is mediated by the osteoclast. Growth factors, including transforming growth factor-beta (TGF-beta), released from bone matrix by the action of osteoclasts, may foster metastatic growth. Because TGF-beta inhibits growth of epithelial cells, and carcinoma cells are often defective in TGF-beta responses, any role of TGF-beta...

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Identifiers

PMID: 9916131
DOI: 10.1172/JCI3523
PMCID: PMC407876

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Source receipt: pubmed, retrieved 7 Sept 2026.

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