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Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway

19 Sept 2005

Abstract excerpt

TGF-beta can signal by means of Smad transcription factors, which are quintessential tumor suppressors that inhibit cell proliferation, and by means of Smad-independent mechanisms, which have been implicated in tumor progression. Although Smad mutations disable this tumor-suppressive pathway in certain cancers, breast cancer cells frequently evade the cytostatic action of TGF-beta while retaining Smad function....

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PMID: 16172383
DOI: 10.1073/pnas.0506517102

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