Article
Growth and virulence of a complement-activation-negative mutant of Streptococcus pneumoniae in the rabbit cornea.
Current eye research - 1 Apr 1995
Johnson M K, Callegan M C, Engel L S, O'Callaghan R J, Hill J M, Hobden J A, Boulnois G J, Andrew P W, Mitchell T J
Abstract excerpt
Our previous work has demonstrated the importance of pneumolysin in the virulence of S. pneumoniae in a rabbit intracorneal model. This was accomplished by showing that deletion of the gene encoding pneumolysin resulted in reduced virulence, whereas restoration of the wild-type gene resulted in r...
Topics
- Amino Acid Sequence
- Animals
- Bacterial Proteins
- Base Sequence
- Colony Count, Microbial
- Complement Activation
- Cornea
- DNA, Bacterial
- Eye Infections, Bacterial
- Gene Expression Regulation, Bacterial
- Keratitis
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation