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Article

Growth and virulence of a complement-activation-negative mutant of Streptococcus pneumoniae in the rabbit cornea.

Current eye research - 1 Apr 1995

Johnson M K, Callegan M C, Engel L S, O'Callaghan R J, Hill J M, Hobden J A, Boulnois G J, Andrew P W, Mitchell T J

Abstract excerpt

Our previous work has demonstrated the importance of pneumolysin in the virulence of S. pneumoniae in a rabbit intracorneal model. This was accomplished by showing that deletion of the gene encoding pneumolysin resulted in reduced virulence, whereas restoration of the wild-type gene resulted in restoration of the virulent phenotype. To assess the importance of a particular domain in the pneumolysin molecule, we...

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Identifiers

PMID: 7606914
DOI: 10.3109/02713689509033527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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