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Article

Pleiotrophin and midkine, a family of mitogenic and angiogenic heparin–binding growth and differentiation factors

1 Jan 1999

Abstract excerpt

The heparin-binding polypeptide homologs pleiotrophin and midkine are the only known members of a family of secreted growth/differentiation cytokines. Pleiotrophin and midkine are both developmentally regulated and highly conserved among species. They signal a number of physiological functions involved with angiogenesis, neuorogenesis, cell migration, and mesoderm-epithelial interactions. Constitutive expression...

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Identifiers

PMID: 9915553
DOI: 10.1097/00062752-199901000-00008

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Source receipt: pubmed, retrieved 7 Sept 2026.

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