Article
Three molecular determinants of malignant conversion and their potential as therapeutic targets.
Current opinion in oncology - 1 Jan 1999
Dome J S, Look A T
Abstract excerpt
The past decade has been marked by an explosion of knowledge regarding the dysregulation of cancer at the molecular level. It has become apparent that oncogenes, tumor suppressor genes, and other ancillary molecules interact in complex pathways that govern cellular homeostasis. We review three mo...
Topics
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p16
- Enzyme Activation
- Gene Expression Regulation, Neoplastic
- Hedgehog Proteins
- Humans
- Models, Genetic
- Mutation
- Neoplasms
- Proteins
- Telomerase
- Trans-Activators