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MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases.

Endocrine-related cancer - 1 Sept 2010

Corbo Vincenzo, Dalai Irene, Scardoni Maria, Barbi Stefano, Beghelli Stefania, Bersani Samantha, Albarello Luca, Doglioni Claudio, Schott Christina, Capelli Paola, Chilosi Marco, Boninsegna Letizia, Becker Karl-Friedrich, Falconi Massimo, Scarpa Aldo

Abstract excerpt

Pancreatic endocrine tumors (PETs) may be part of hereditary multiple endocrine neoplasia type 1 (MEN1) syndrome. While MEN1 gene mutation is the only ascertained genetic anomaly described in PETs, no data exist on the cellular localization of MEN1-encoded protein, menin, in normal pancreas and PETs. A total of 169 PETs were used to assess the i) MEN1 gene mutational status in 100 clinically sporadic PETs by...

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PMID: 20566584
DOI: 10.1677/ERC-10-0028

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MEN1

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