Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SHP-1 protein tyrosine phosphatase associates with the adaptor protein CrkL.

Experimental hematology - 1 Dec 2012

Evren Sevan, Ma Xue-Zhong, Sakac Darinka, Branch Donald R

Abstract excerpt

SHP-1, encoded by the PTPN6 gene, is a protein tyrosine phosphatase with two src-homology-2 (SH2) domains that is implicated as providing suppression of hematopoietic malignancies. A number of reports have shown protein-protein interactions between SHP-1 SH2 domains and tyrosine-phosphorylated proteins. However, despite its having three proline-rich, potential SH3-binding motifs, no reports of protein-protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Amino Acid Motifs
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Weight

Share to Mutation

Share to Nuclear Proteins

Share to Protein Binding

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 6

Source

Identifiers

PMID: 22960265
DOI: 10.1016/j.exphem.2012.08.007

Genes

PTPN6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SHP-1 protein tyrosine phosphatase associates with the adaptor protein CrkL.PMID 22960265Read ↗

Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer TherapySemantic proximity Read ↗

The Role of Shcbp1 in Signaling and DiseaseSemantic proximity Read ↗

Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase.Semantic proximity Read ↗

Binding specificity and mutational analysis of the phosphotyrosine binding domain of the brain-specific adaptor protein ShcC.Semantic proximity Read ↗

Tyrosine-phosphorylated low density lipoprotein receptor-related protein 1 (Lrp1) associates with the adaptor protein SHC in SRC-transformed cells.Semantic proximity Read ↗

Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes.Semantic proximity Read ↗

The Emerging and Diverse Roles of Src‐Like Adaptor Proteins in Health and DiseaseSemantic proximity Read ↗

Crk family adaptor proteins trans-activate c-Abl kinase.Semantic proximity Read ↗

The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.Semantic proximity Read ↗

A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1.Semantic proximity Read ↗

Non-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptor.Semantic proximity Read ↗

Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.