Article
SHP-1 protein tyrosine phosphatase associates with the adaptor protein CrkL.
Experimental hematology - 1 Dec 2012
Evren Sevan, Ma Xue-Zhong, Sakac Darinka, Branch Donald R
Abstract excerpt
SHP-1, encoded by the PTPN6 gene, is a protein tyrosine phosphatase with two src-homology-2 (SH2) domains that is implicated as providing suppression of hematopoietic malignancies. A number of reports have shown protein-protein interactions between SHP-1 SH2 domains and tyrosine-phosphorylated proteins. However, despite its having three proline-rich, potential SH3-binding motifs, no reports of protein-protein...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Motifs
- Cell Line, Tumor
- Humans
- Molecular Weight
- Mutation
- Nuclear Proteins
- Protein Binding
- Protein Tyrosine Phosphatase, Non-Receptor Type 6