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Article

Valproate robustly enhances AP-1 mediated gene expression.

Brain research. Molecular brain research - 22 Jan 1999

Chen G, Yuan P X, Jiang Y M, Huang L D, Manji H K

Abstract excerpt

Valproic acid (VPA) is a potent broad spectrum anticonvulsant with demonstrated efficacy in the treatment of Bipolar Affective Disorder, but the biochemical basis for VPA's antimanic or mood-stabilizing actions have not been fully elucidated. It has been demonstrated that VPA, at therapeutically relevant concentrations, increases AP-1 DNA binding activity in cultured cells in vitro. These findings raise the...

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PMID: 9889318
DOI: 10.1016/s0169-328x(98)00303-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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