Valproate robustly enhances AP-1 mediated gene expression.

doi:10.1016/s0169-328x(98)00303-9

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Article

Valproate robustly enhances AP-1 mediated gene expression.

Brain research. Molecular brain research - 22 Jan 1999

Chen G, Yuan P X, Jiang Y M, Huang L D, Manji H K

Abstract excerpt

Valproic acid (VPA) is a potent broad spectrum anticonvulsant with demonstrated efficacy in the treatment of Bipolar Affective Disorder, but the biochemical basis for VPA's antimanic or mood-stabilizing actions have not been fully elucidated. It has been demonstrated that VPA, at therapeutically...

Topics

Animals
Anticonvulsants
Bipolar Disorder
DNA-Binding Proteins
Gene Expression Regulation
Genes, Reporter
Glioma
Humans
Luciferases
Molecular Sequence Data
Mutation
Neuroblastoma
Neurons
Proto-Oncogene Proteins c-fos
Proto-Oncogene Proteins c-jun
Rats
Sequence Homology, Amino Acid
Transcription Factor AP-1

Source

Open in PubMed

Identifiers

PMID: 9889318
DOI: 10.1016/s0169-328x(98)00303-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9889318-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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