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Article

Lithium and valproic acid: parallels and contrasts in diverse signaling contexts.

Pharmacology & therapeutics - 1 Oct 2002

Gurvich Nadia, Klein Peter S

Abstract excerpt

The introduction of lithium salts to treat bipolar disorder (BPD) revolutionized the therapy of psychiatric illnesses, but the pathogenesis of the disease and the mechanism of lithium action remain unknown. While several direct molecular targets of lithium have been identified, it is unknown which, if any, of these targets plays a role in the therapeutic response to lithium. Exposure to lithium evokes a wide...

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Identifiers

PMID: 12441177
DOI: 10.1016/s0163-7258(02)00299-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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