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Valproic acid for the treatment of myeloid malignancies

23 Jul 2007

Abstract excerpt

Valproic acid (VPA) has been used as an anticonvulsant for decades. Recently, it was demonstrated that VPA also acts as a histone deacetylase inhibitor and induces differentiation and apoptosis in a variety of malignant cells in vitro. The effect of VPA on tumor cells differs according to cell type, degree of differentiation, and underlying genetic alterations. Clinical trials with VPA have focused on acute...

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PMID: 17647267
DOI: 10.1002/cncr.22891

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