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Article

Sp family of transcription factors is involved in valproic acid-induced expression of Galphai2.

The Journal of biological chemistry - 16 May 2003

Arinze Ifeanyi J, Kawai Yumiko

Abstract excerpt

Valproic acid-induced gene expression has been attributed to the DNA-binding activity of the transcription factor activator protein 1 (AP-1). Using K562 cells, we have studied valproic acid-induced transcription from the human Galpha(i2) gene promoter, which lacks AP-1-binding motifs. We find that valproic acid-induced expression of Galpha(i2) is inhibited by mithramycin A, a compound that interferes with Sp1...

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PMID: 12624107
DOI: 10.1074/jbc.M209430200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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