Trapidil-mediated inhibition of CNS remyelination results from reduced numbers and impaired differentiation of oligodendrocytes.

doi:10.1046/j.1365-2990.1998.00148.x

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Article

Trapidil-mediated inhibition of CNS remyelination results from reduced numbers and impaired differentiation of oligodendrocytes.

Neuropathology and applied neurobiology - 1 Dec 1998

McKay J S, Blakemore W F, Franklin R J

Abstract excerpt

In a previous study, we described the inhibitory effects of the growth factor-antagonist, trapidil, on spontaneously occurring oligodendrocyte remyelination in the rat spinal cord following lysolecithin-induced demyelination [30]. The objective of the present study was to further investigate the...

Topics

Animals
Cell Count
Cell Differentiation
Female
Growth Inhibitors
Growth Substances
Myelin Sheath
Nerve Regeneration
Oligodendroglia
Phenotype
Rats
Trapidil

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