Article
Ventral root avulsion: an experimental model of death of adult motor neurons.
The Journal of comparative neurology - 1 Apr 1994
Koliatsos V E, Price W L, Pardo C A, Price D L
Abstract excerpt
The present study proposes a reproducible model of experimental degeneration of adult motor neurons in the rat. Avulsion of ventral roots in the adult lumbar cord transects motor axons at the root exit and leads to retrograde cell death of 80% of motor neurons 2 weeks later; this result follows a...
Topics
- Animals
- Axons
- Choline O-Acetyltransferase
- Fluorescent Dyes
- Immunohistochemistry
- Male
- Models, Biological
- Motor Neurons
- Neurons, Afferent
- Phenotype
- Rats
- Rats, Sprague-Dawley
- Retrograde Degeneration
- Sciatic Nerve
- Spinal Nerve Roots
- Stilbamidines