Article
PTEN mutations in endometrial cancers with 10q LOH: additional evidence for the involvement of multiple tumor suppressors.
Gynecologic oncology - 1 Dec 1998
Simpkins S B, Peiffer-Schneider S, Mutch D G, Gersell D, Goodfellow P J
Abstract excerpt
OBJECTIVE: The aim of this study was to assess the involvement of PTEN and other putative 10q tumor suppressors in endometrioid-type adenocarcinomas characterized by loss of 10q sequences. METHODS: PCR-based single-stranded conformational variant analysis and sequencing of individual PTEN exons i...
Topics
- Endometrial Neoplasms
- Female
- Genes, Tumor Suppressor
- Humans
- Loss of Heterozygosity
- Mutation
- PTEN Phosphohydrolase
- Phosphoric Monoester Hydrolases
- Sequence Analysis, DNA
- Tumor Suppressor Proteins