The Human RC3 Gene Homolog, NRGN Contains a Thyroid Hormone-Responsive Element Located in the First Intron**This work was supported by grants from Fundacion Ramon Areces and DGICYT (PM95–0019).

Abstract excerpt

NRGN is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic 78-amino acid protein kinase substrate that binds calmodulin in the absence of calcium, and that has been implicated in dendritic spine formation and synaptic plasticity. In the rat brain RC3 is under thyroid hormone control in specific neuronal subsets in both developing and adult animals. To evaluate...

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