Article
Influence of thyroid hormone on brain gene expression.
Acta medica Austriaca - 1 Jan 1992
Bernal J, Rodriguez-Pena A, Iniguez M A, Ibarrola N, Munoz A
Abstract excerpt
Brain development in mammals is dependent on thyroid hormone. In the rat, the T3 receptor is present as early as the 14th day of fetal life and increases during the periods of neuroblast proliferation and oligodendrocyte differentiation. The mRNAs encoding the receptor isoforms can also be demonstrated by in situ hybridization, with different distribution of the alpha or beta forms. Expression of several genes...
Topics
- Animals
- Brain
- Calmodulin-Binding Proteins
- Gene Expression Regulation
- Humans
- Myelin Proteins
- Nerve Tissue Proteins
- Neurogranin
- Phenotype
- Receptors, Thyroid Hormone
- Species Specificity
