Article
The first dose of a Haemophilus influenzae type b conjugate vaccine reactivates memory B cells: evidence for extensive clonal selection, intraclonal affinity maturation, and multiple isotype switches to IgA2.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 1999
Hougs L, Juul L, Ditzel H J, Heilmann C, Svejgaard A, Barington T
Abstract excerpt
The Ab response of a healthy adult to the first dose of a Haemophilus influenzae type b capsular polysaccharide (HibCP) conjugate vaccine was studied at the level of Ig gene usage by circulating Ab-secreting cells. Forty-one IgA and 17 IgG mRNA sequences were obtained. The major part of the respo...
Topics
- Adult
- Amino Acid Sequence
- Antibody Affinity
- B-Lymphocyte Subsets
- Bacterial Capsules
- Base Sequence
- Cell Differentiation
- Clone Cells
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Haemophilus Vaccines
- Humans
- Immunization Schedule