Article
Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutation.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1993
Ikematsu H, Harindranath N, Ueki Y, Notkins A L, Casali P
Abstract excerpt
The construction of mAb-producing cell lines has been instrumental in dissecting the fine specificities and genetic makeup of murine antibodies to exogenous and self Ag. The analysis of the genetic composition of human antibody responses has been hampered by the difficulty in generating human mAb...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Antibody Affinity
- Antibody Diversity
- Antigens, Viral
- Base Sequence
- Clone Cells
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Variable Region
- Molecular Sequence Data