Somatic hypermutation in T-independent and T-dependent immune responses to Haemophilus influenzae type b polysaccharide.

Abstract excerpt

Secondary immune responses to T-independent antigens are characterized by little or no affinity maturation, a phenomenon attributed to limited somatic hypermutation. In the human immune response to Haemophilus influenzae type b capsular polysaccharide, however, there are numerous differences between rearranged heavy chain variable region gene segments and candidate germline genes, irrespective of antigen...

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