Article
Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of V kappa and V lambda segments and VJ combinations.
The Journal of clinical investigation - 1 Mar 1992
Adderson E E, Shackelford P G, Insel R A, Quinn A, Wilson P M, Carroll W L
Abstract excerpt
The immune repertoire to Haemophilus influenzae type b capsular polysaccharide (Hib PS) appears to be dominated by certain light chain variable region genes (IgVL). In order to examine the molecular basis underlying light chain bias, IgVL genes have been cloned from a panel of heterohybridomas secreting human anti-Hib PS (antibody) (anti-Hib PS Ab). One hybridoma, representative of the predominant serum clonotype...
Topics
- Adult
- Age Factors
- Amino Acid Sequence
- Antibodies, Bacterial
- Bacterial Capsules
- Bacterial Vaccines
- Base Sequence
- Blotting, Southern
- Child
- Child, Preschool