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Article

Structural and functional analysis of the cytidine deaminase gene in patients with acute myeloid leukaemia.

British journal of haematology - 1 Dec 1998

Schröder J K, Kirch C, Seeber S, Schütte J

Abstract excerpt

Gene transfer of the cytidine deaminase (CDD) cDNA has recently been shown to induce cellular resistance to cytarabine (AraC) in vitro. To investigate the role for CDD in acute myeloid leukaemia (AML) we analysed the CDD activity and CDD gene structure in blast material from well-defined patients...

Topics

Acute Disease
Adult
Aged
Antibiotics, Antineoplastic
Antimetabolites, Antineoplastic
Blotting, Southern
Cytarabine
Cytidine Deaminase
Drug Resistance, Neoplasm
Humans
Idarubicin
Leukemia, Myeloid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Polymorphism, Genetic

Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 9886326
DOI: 10.1046/j.1365-2141.1998.01084.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9886326-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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