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Article

Deoxycytidine Kinase (DCK) Mutations in Human Acute Myeloid Leukemia Resistant to Cytarabine.

Acta haematologica - 1 Jan 2000

Wu Biao, Mao Zhengwei Jenny, Wang Zhi, Wu Pin, Huang Hongyu, Zhao Wenjun, Zhang Lei, Zhang Zhou, Yin Hongchao, Gale Robert Peter, Yin Bin

Abstract excerpt

Resistance to cytarabine is an important cause of therapy failure in persons with acute myeloid leukemia (AML). Deoxycytidine kinase, encoded by DCK, catalyzes phosphorylation of cytarabine to cytarabine monophosphate, a necessary step for eventual incorporation of cytarabine triphosphate into DNA and for clinical efficacy. Whether DCK mutations make AML cells resistant to cytarabine is controversial. We studied...

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PMID: 33626530
DOI: 10.1159/000513696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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