Recombinant gene products of two natural variants of the human cytidine deaminase gene confer different deamination rates of cytarabine in vitro.

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Article

Recombinant gene products of two natural variants of the human cytidine deaminase gene confer different deamination rates of cytarabine in vitro.

Experimental hematology - 1 May 1998

Kirch H C, Schröder J, Hoppe H, Esche H, Seeber S, Schütte J

Abstract excerpt

The recent cloning of human cytidine deaminase (CDD) revealed two variants with a nonconservative amino acid deviation (Gln<-->Lys) at codon 27 within a region of structural homology to a core domain of bacterial CDDs. We here confirm the occurrence of both CDD sequences by cDNA cloning and show...

Topics

Cytarabine
Cytidine
Cytidine Deaminase
DNA, Complementary
Deamination
Drug Resistance, Neoplasm
Genetic Variation
Humans
Recombinant Proteins
Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 9590659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9590659-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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