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Article

High incidence of alternatively spliced forms of deoxycytidine kinase in patients with resistant acute myeloid leukemia

15 Aug 2000

Abstract excerpt

Deficiency of functional deoxycytidine kinase (dCK) is a common characteristic for in vitro resistance to cytarabine (AraC). To investigate whether dCK is also a target for induction of AraC resistance in patients with acute myeloid leukemia (AML), we determined dCK messenger RNA (mRNA) expression in (purified) leukemic blasts and phytohemagglutinin-stimulated T cells (PHA T cells) from patients with...

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PMID: 10942400
DOI: 10.1182/blood.v96.4.1517

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