Article
Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to type I diabetes: analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice.
International immunology - 1 Dec 1998
Boyton R J, Lohmann T, Londei M, Kalbacher H, Halder T, Frater A J, Douek D C, Leslie D G, Flavell R A, Altmann D M
Abstract excerpt
Glutamic acid decarboxylase (GAD65) has been implicated as a targeted self antigen in the immune destruction of pancreatic beta cells. T cell responses to GAD65 peptides have been detected in both patients with type I diabetes and in the non-obese diabetic (NOD) mouse. To establish which GAD65 ep...
Topics
- Adult
- Amino Acid Sequence
- Animals
- Cells, Cultured
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
- Diseases in Twins
- Epitopes, T-Lymphocyte
- Genetic Predisposition to Disease
- Glutamate Decarboxylase
- HLA-DQ Antigens
- Humans