Article
The role of MHC class II molecules in susceptibility to type I diabetes: identification of peptide epitopes and characterization of the T cell repertoire.
Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 1999
Chao C C, Sytwu H K, Chen E L, Toma J, McDevitt H O
Abstract excerpt
Susceptibility to type I diabetes is linked to class II MHC alleles in both mouse and man. However, the molecular mechanisms by which MHC molecules mediate disease susceptibility are unknown. To analyze how I-A alleles predispose to, or prevent, the development of type I diabetes, we have chosen, as the first step, to investigate the immune response to an important islet cell protein in diabetes-susceptible and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.