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Article

Circulating activated protein C in subjects with heterozygous Gln506-factor V.

Haemostasis - 1 Jan 2000

Petäjä J, Hakala L, Rasi V, Griffin J H

Abstract excerpt

Congenital resistance to activated protein C due to a point mutation in the factor V gene (Gln506-FV) is the most common genetic risk factor for familial venous thrombosis. Considering the central role of activated protein C as a physiological anticoagulant, the question of why the thrombotic risk associated with Gln506-FV was not more pronounced was asked. We hypothesized that in Gln506-FV heterozygotes,...

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Identifiers

PMID: 9885368
DOI: 10.1159/000022381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Circulating activated protein C in subjects with heterozygous Gln506-factor V.PMID 9885368Read ↗

Incidence of activated protein C resistance caused by the ARG 506 GLN mutation in factor V in 113 unrelated symptomatic protein C-deficient patients. The French Network on the behalf of INSERM.Semantic proximity Read ↗

Resistance to activated protein C, the FV:Q506 allele, and venous thrombosis.Semantic proximity Read ↗

New molecular insights into the genetics of thrombophilia. Resistance to activated protein C caused by Arg506 to Gln mutation in factor V as a pathogenic risk factor for venous thrombosis.Semantic proximity Read ↗

Elevated Levels of Prothrombin Activation Fragment 1+2 in Plasma from Patients with Heterozygous Arg506 to Gin Mutation in the Factor V Gene (APC-Resistance) and/or Inherited Protein S DeficiencySemantic proximity Read ↗

Resistance to activated protein C caused by the R506Q mutation in the gene for factor V is a common risk factor for venous thrombosis.Semantic proximity Read ↗

Inherited resistance to activated protein C caused by presence of the FV:Q506 allele as a basis of venous thrombosis.Semantic proximity Read ↗

Resistance to activated protein C caused by the factor VR506Q mutation is a common risk factor for venous thrombosis.Semantic proximity Read ↗

Activated protein C resistance--a major risk factor for thrombosis.Semantic proximity Read ↗

Clinical studies and thrombin generation in patients homozygous or heterozygous for the G20210A mutation in the prothrombin gene.Semantic proximity Read ↗

Prothrombin activity and concentration in healthy subjects with and without the prothrombin G20210A mutation.Semantic proximity Read ↗

Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C.Semantic proximity Read ↗

Arterial and venous thrombosis in two Italian families with the factor V Arg506-->Gln mutation.Semantic proximity Read ↗

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