Article
Aphakia (ak), a mouse mutation affecting early eye development: fine mapping, consideration of candidate genes and altered Pax6 and Six3 gene expression pattern.
Developmental genetics - 1 Jan 1998
Grimm C, Chatterjee B, Favor J, Immervoll T, Löster J, Klopp N, Sandulache R, Graw J
Abstract excerpt
The homozygous mouse mutant aphakia (ak) has been characterized by bilaterally aphakic eyes without a pupil [Varnum DS, Stevens, LC (1968): J Hered 59:147-150]. The mutation was mapped to chromosome 19 [Varnum DS, Stevens, LC (1975): Mouse News Lett 53:35]. Our linkage studies yielded a precise l...
Topics
- Animals
- Chromosome Mapping
- DNA-Binding Proteins
- Eye
- Eye Proteins
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Mice
- Mice, Mutant Strains
- Mutation
- Nerve Tissue Proteins
- PAX6 Transcription Factor
- Paired Box Transcription Factors
- Repressor Proteins