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Article

Foxe view of lens development and disease.

Development (Cambridge, England) - 1 Apr 2007

Medina-Martinez Olga, Jamrich Milan

Abstract excerpt

The recent identification of a mutation in Foxe3 that causes congenital primary aphakia in humans marks an important milestone. Congenital primary aphakia is a rare developmental disease in which the lens does not form. Previously, Foxe3 had been shown to play a crucial role in vertebrate lens formation and this gene is one of the earliest integrators of several signaling pathways that cooperate to form a lens....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17344231
DOI: 10.1242/dev.000117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Foxe view of lens development and disease.PMID 17344231Read ↗

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Lack of FOXE3 coding mutation in a case of congenital aphakia.Semantic proximity Read ↗

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Forkhead Foxe3 maps to the dysgenetic lens locus and is critical in lens development and differentiation.Semantic proximity Read ↗

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FOXE3 mutations: genotype-phenotype correlations.Semantic proximity Read ↗

Homozygous Nonsense Mutation in the FOXE3 Gene as a Cause of Congenital Primary Aphakia in HumansSemantic proximity Read ↗

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A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle.Semantic proximity Read ↗

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