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Article

Foxe view of lens development and disease.

Development (Cambridge, England) - 1 Apr 2007

Medina-Martinez Olga, Jamrich Milan

Abstract excerpt

The recent identification of a mutation in Foxe3 that causes congenital primary aphakia in humans marks an important milestone. Congenital primary aphakia is a rare developmental disease in which the lens does not form. Previously, Foxe3 had been shown to play a crucial role in vertebrate lens fo...

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Share to Connexins and lens biology
Share to Eye Diseases, Hereditary
Share to Forkhead Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Intraocular Surgery and Lenses

Share to Lens, Crystalline

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Source

Identifiers

PMID: 17344231
DOI: 10.1242/dev.000117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17344231-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Foxe view of lens development and disease.PMID 17344231Read ↗

Seeing clearly: the dominant and recessive nature of FOXE3 in eye developmental anomalies.Semantic proximity Read ↗

A zebrafish model of foxe3 deficiency demonstrates lens and eye defects with dysregulation of key genes involved in cataract formation in humans.Semantic proximity Read ↗

Lack of FOXE3 coding mutation in a case of congenital aphakia.Semantic proximity Read ↗

Comprehensive phenotypic and functional analysis of dominant and recessive FOXE3 alleles in ocular developmental disorders.Semantic proximity Read ↗

Forkhead Foxe3 maps to the dysgenetic lens locus and is critical in lens development and differentiation.Semantic proximity Read ↗

Mutations in the human forkhead transcription factor FOXE3 associated with anterior segment ocular dysgenesis and cataracts.Semantic proximity Read ↗

FOXE3 mutations: genotype-phenotype correlations.Semantic proximity Read ↗

Homozygous Nonsense Mutation in the FOXE3 Gene as a Cause of Congenital Primary Aphakia in HumansSemantic proximity Read ↗

Eye development.Semantic proximity Read ↗

A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle.Semantic proximity Read ↗

Congenital eye anomalies: More mosaic than thought?Semantic proximity Read ↗

Developmental eye disorders.Semantic proximity Read ↗

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