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Article

A double-deletion mutation in the Pitx3 gene causes arrested lens development in aphakia mice.

Genomics - 15 Feb 2001

Rieger D K, Reichenberger E, McLean W, Sidow A, Olsen B R

Abstract excerpt

The recessive aphakia (ak) mouse mutant is characterized by bilateral microphthalmia due to a failure of lens morphogenesis. We fine-mapped the ak locus to the interval between D19Umi1 and D19Mit9, developed new polymorphic markers, and mapped candidate genes by construction of a BAC contig. The Pitx3 gene, known to be expressed in lens primordia, shows zero recombination with the ak mutation on our...

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Source

Identifiers

PMID: 11247667
DOI: 10.1006/geno.2000.6464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A double-deletion mutation in the Pitx3 gene causes arrested lens development in aphakia mice.PMID 11247667Read ↗

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