Article
Mouse small eye results from mutations in a paired-like homeobox-containing gene.
Nature - 1 Jan 2000
Hill R E, Favor J, Hogan B L, Ton C C, Saunders G F, Hanson I M, Prosser J, Jordan T, Hastie N D, van Heyningen V
Abstract excerpt
Small eye (Sey) in mouse is a semidominant mutation which in the homozygous condition results in the complete lack of eyes and nasal primordia. On the basis of comparative mapping studies and on phenotypic similarities, Sey has been suggested to be homologous to congenital aniridia (lack of iris) in human. A candidate gene for the aniridia (AN) locus at 11p13 has been isolated by positional cloning and its...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Southern
- Chromosome Deletion
- Cloning, Molecular
- Crosses, Genetic
- Embryo, Mammalian
- Embryonic and Fetal Development
- Eye