Article
A T1083C polymorphism in the human adenosine A2a receptor gene is not associated with essential hypertension.
American journal of hypertension - 1 Dec 1998
Soma M, Nakayama T, Satoh M, Uwabo J, Rahmutula D, Takahashi Y, Fukuda N, Watanabe Y, Izumi Y, Kanmatsuse K
Abstract excerpt
The adenosine A2a receptor (A2aAR) gene is thought to be involved in essential hypertension because adenosine elicits vasodilation and decreases arterial blood pressure via this receptor, and because disruption of the A2aAR gene increases blood pressure in mice. Therefore, using a restriction fragment length polymorphism (RFLP) of the A2aAR gene, we performed an association study in patients with essential...
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