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ERK-Mediated Phosphorylation of EZH2 Regulates HER2 Expression on Long-term Genistein-induced Acquired Endocrine Resistance in Estrogen-Receptor-Positive Breast Cancer Cells

2020-11-19

Abstract excerpt

<h4>Background: </h4> Genistein, a soy isoflavones, is the most important phytoestrogens in typical oriental diet. Many studies have shown that genistein at lower concentrations promotes breast cancer cells growth through the estrogen receptor pathway. However, recent research has found that long-term consumption of low doses of genistein results in hormone-independent growth phenotypes of MCF-7 tumors, with incre...

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Literature Corpus work: 023ddea4-6da1-5226-bf16-0665ba225e0e
DOI: 10.21203/rs.3.rs-108061/v1

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