Article
Estrogen receptors in membrane lipid rafts and signal transduction in breast cancer.
Molecular and cellular endocrinology - 26 Feb 2006
Márquez Diana C, Chen Hsiao-Wang, Curran Edward M, Welshons Wade V, Pietras Richard J
Abstract excerpt
Regulation of breast cancer growth by estrogen is mediated by estrogen receptors (ER) in nuclear and extranuclear compartments. We assessed the structure and functions of extranuclear ER that initiate downstream signaling to the nucleus. ER, including full-length 66-kDa ER and a 46-kDa ER splice variant, are enriched in lipid rafts from MCF-7 cells with (MCF-7/HER-2) or without (MCF-7/PAR) HER-2 gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.