Article
A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling.
Developmental cell - 1 Apr 2004
Ceol Craig J, Horvitz H R
Abstract excerpt
The class A and class B synMuv genes are functionally redundant negative regulators of a Ras signaling pathway that induces C. elegans vulval development. A number of class B synMuv genes encode components of an Rb and histone deacetylase complex that likely acts to repress transcription of genes...
Topics
- Acetyltransferases
- Adaptor Proteins, Signal Transducing
- Adenosine Triphosphatases
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Lineage
- Chromosomal Proteins, Non-Histone
- DNA, Complementary
- Female
- Gene Expression Regulation, Developmental
- Histone Acetyltransferases
- Histone Deacetylases
- Lysine Acetyltransferase 5
- Macromolecular Substances
- Membrane Glycoproteins
- Molecular Sequence Data
- Mutation