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Article

C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates.

Development (Cambridge, England) - 1 Jul 2006

Andersen Erik C, Lu Xiaowei, Horvitz H Robert

Abstract excerpt

The class A, B and C synthetic multivulva (synMuv) genes act redundantly to negatively regulate the expression of vulval cell fates in Caenorhabditis elegans. The class B and C synMuv proteins include homologs of proteins that modulate chromatin and influence transcription in other organisms similar to members of the Myb-MuvB/dREAM, NuRD and Tip60/NuA4 complexes. To determine how these chromatin-remodeling...

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PMID: 16774993
DOI: 10.1242/dev.02444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates.PMID 16774993Read ↗

A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling.Semantic proximity Read ↗

Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans.Semantic proximity Read ↗

Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.Semantic proximity Read ↗

Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development.Semantic proximity Read ↗

LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes.Semantic proximity Read ↗

dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development.Semantic proximity Read ↗

lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.Semantic proximity Read ↗

Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motif.Semantic proximity Read ↗

Multiple levels of redundant processes inhibit Caenorhabditis elegans vulval cell fates.Semantic proximity Read ↗

SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans.Semantic proximity Read ↗

Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity.Semantic proximity Read ↗

gon-14 functions with class B and class C synthetic multivulva genes to control larval growth in Caenorhabditis elegans.Semantic proximity Read ↗

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