Article
Characterization of human γδ T lymphocytes infiltrating primary malignant melanomas.
PloS one - 1 Jan 2012
Cordova Adriana, Toia Francesca, La Mendola Carmela, Orlando Valentina, Meraviglia Serena, Rinaldi Gaetana, Todaro Matilde, Cicero Giuseppe, Zichichi Leonardo, Donni Paolo Li, Caccamo Nadia, Stassi Giorgio, Dieli Francesco, Moschella Francesco
Abstract excerpt
T lymphocytes are often induced naturally in melanoma patients and infiltrate tumors. Given that γδ T cells mediate antigen-specific killing of tumor cells, we studied the representation and the in vitro cytokine production and cytotoxic activity of tumor infiltrating γδ T cells from 74 patients with primary melanoma. We found that γδ T cells represent the major lymphocyte population infiltrating melanoma, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.