Article
Prevalence of nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance-associated mutations and polymorphisms in NNRTI-naïve HIV-infected patients.
HIV clinical trials - 1 Jan 2000
Clevenbergh P, Cua E, Dam E, Durant J, Schmit J C, Boulme R, Cottalorda J, Beyou A, Schapiro J M, Clavel F, Dellamonica P
Abstract excerpt
BACKGROUND: The efficacy of treatment containing nonnucleoside reverse transcriptase inhibitors (NNRTIs) could be compromised in NNRTI-naïve patients already harboring a virus resistant to NNRTIs. On the contrary, hypersusceptibility to NNRTIs in patients having failed nucleoside reverse transcriptase inhibitor (NRTI)-containing regimens has been described and has been associated with improved outcome. METHOD: We...
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