Article
Changes in keratin and filaggrin expression in the skin of chronic proliferative dermatitis (cpdm) mutant mice.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 1999
HogenEsch H, Boggess D, Sundberg J P
Abstract excerpt
The expression of keratins and filaggrin by keratinocytes is a highly regulated process and depends on their state of differentiation and proliferation. As such, these proteins can be used as markers to determine if keratinocyte differentiation is normal. Mutant cpdm/cpdm mice develop a chronic skin disease characterized by epidermal hyperplasia and inflammation. Immunohistochemical staining for the basal...
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