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Article

An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate.

PloS one - 20 May 2009

Romano Rose-Anne, Ortt Kori, Birkaya Barbara, Smalley Kirsten, Sinha Satrajit

Abstract excerpt

BACKGROUND: One major defining characteristic of the basal keratinocytes of the stratified epithelium is the expression of the keratin genes K5 and K14. The temporal and spatial expression of these two genes is usually tightly and coordinately regulated at the transcriptional level. This ensures the obligate pairing of K5 and K14 proteins to generate an intermediate filament (IF) network that is essential for the...

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Identifiers

PMID: 19461998
DOI: 10.1371/journal.pone.0005623
PMCID: PMC2680039

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