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Article

Keratin 9 is required for the structural integrity and terminal differentiation of the palmoplantar epidermis.

The Journal of investigative dermatology - 1 Mar 2014

Fu Dun Jack, Thomson Calum, Lunny Declan P, Dopping-Hepenstal Patricia J, McGrath John A, Smith Frances J D, Irwin McLean W H, Leslie Pedrioli Deena M

Abstract excerpt

Keratin 9 (K9) is a type I intermediate filament protein whose expression is confined to the suprabasal layers of the palmoplantar epidermis. Although mutations in the K9 gene are known to cause epidermolytic palmoplantar keratoderma, a rare dominant-negative skin disorder, its functional significance is poorly understood. To gain insight into the physical requirement and importance of K9, we generated...

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Source

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Identifiers

PMID: 23962810
DOI: 10.1038/jid.2013.356
PMCID: PMC3923277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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