Inferring the fitness effects of DNA mutations from polymorphism and divergence data: statistical power to detect directional selection under stationarity and free recombination.

Abstract excerpt

The fitness effects of classes of DNA mutations can be inferred from patterns of nucleotide variation. A number of studies have attributed differences in levels of polymorphism and divergence between silent and replacement mutations to the action of natural selection. Here, I investigate the stat...

Topics

• Adaptation, Biological
• Animals
• DNA
• Drosophila
• Evolution, Molecular
• Genes, Insect
• Insect Proteins
• Mathematical Computing
• Models, Genetic
• Mutation
• Polymorphism, Genetic
• Recombination, Genetic