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Article

Genomic effects of nucleotide substitutions in Drosophila simulans.

Genetics - 1 Dec 2002

Kern Andrew D, Jones Corbin D, Begun David J

Abstract excerpt

Selective fixation of beneficial mutations reduces levels of linked, neutral variation. The magnitude of this "hitchhiking effect" is determined by the strength of selection and the recombination rate between selected and neutral sites. Thus, depending on the values of these parameters and the frequency with which directional selection occurs, the genomic scale over which directional selection reduces levels of...

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Identifiers

PMID: 12524346
DOI: 10.1093/genetics/162.4.1753
PMCID: PMC1462383

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