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Article

Inferring weak selection from patterns of polymorphism and divergence at "silent" sites in Drosophila DNA.

Genetics - 1 Feb 1995

Akashi H

Abstract excerpt

Patterns of codon usage and "silent" DNA divergence suggest that natural selection discriminates among synonymous codons in Drosophila. "Preferred" codons are consistently found in higher frequencies within their synonymous families in Drosophila melanogaster genes. This suggests a simple model of silent DNA evolution where natural selection favors mutations from unpreferred to preferred codons (preferred...

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Identifiers

PMID: 7713409
DOI: 10.1093/genetics/139.2.1067
PMCID: PMC1206357

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