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Article

Inferring weak selection from patterns of polymorphism and divergence at "silent" sites in Drosophila DNA.

Genetics - 1 Feb 1995

Akashi H

Abstract excerpt

Patterns of codon usage and "silent" DNA divergence suggest that natural selection discriminates among synonymous codons in Drosophila. "Preferred" codons are consistently found in higher frequencies within their synonymous families in Drosophila melanogaster genes. This suggests a simple model of silent DNA evolution where natural selection favors mutations from unpreferred to preferred codons (preferred...

Topics

Animals
Base Sequence
Biological Evolution
Codon
DNA
Drosophila
Drosophila melanogaster
Genes, Insect
Models, Genetic
Molecular Sequence Data
Mutation
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7713409
DOI: 10.1093/genetics/139.2.1067
PMCID: PMC1206357

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7713409-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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