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Structural characterization of aminoglycoside 4′‐ O ‐adenylyltransferase ANT(4′)‐IIb from Pseudomonas aeruginosa

31 Dec 2019

Abstract excerpt

Aminoglycosides were one of the first classes of broad-spectrum antibacterial drugs clinically used to effectively combat infections. The rise of resistance to these drugs, mediated by enzymatic modification, has since compromised their utility as a treatment option, prompting intensive research into the molecular function of resistance enzymes. Here, we report the crystal structure of aminoglycoside...

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PMID: 31891426
DOI: 10.1002/pro.3815

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