Molecular determinants of antibiotic recognition and resistance by aminoglycoside phosphotransferase (3')-IIIa: a calorimetric and mutational analysis.

Abstract excerpt

The growing threat from the emergence of multidrug resistant pathogens highlights a critical need to expand our currently available arsenal of broad-spectrum antibiotics. In this connection, new antibiotics must be developed that exhibit the abilities to circumvent known resistance pathways. An important step toward achieving this goal is to define the key molecular interactions that govern antibiotic resistance....

Topics

• Amino Acids
• Anti-Bacterial Agents
• Calorimetry
• Catalysis
• Circular Dichroism
• Coenzymes
• DNA Mutational Analysis
• Drug Resistance, Bacterial
• Escherichia coli
• Hydrogen-Ion Concentration