Article
aph(3')-IIb, a gene encoding an aminoglycoside-modifying enzyme, is under the positive control of surrogate regulator HpaA.
Antimicrobial agents and chemotherapy - 1 Dec 2003
Zeng Lin, Jin Shouguang
Abstract excerpt
Pseudomonas aeruginosa harbors a chromosomal aminoglycoside phosphotransferase gene, aph(3')-IIb, which confers P. aeruginosa resistance to several important aminoglycoside antibiotics, including kanamycin A and B, neomycin B and C, butirosin, and seldomycin F5. The aph(3')-IIb gene has been found to be regulated by an AraC-type transcriptional regulator (HpaA) encoded by a gene located upstream of the...
Topics
- Amino Acid Sequence
- Aminoglycosides
- Anti-Bacterial Agents
- DNA Primers
- Drug Resistance, Bacterial
- Escherichia coli Proteins
- Gene Expression Regulation, Bacterial
- Kanamycin Kinase
- Molecular Sequence Data
- Mutation
- Neomycin
- Operon
- Plasmids
- Pseudomonas aeruginosa