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Article

aph(3')-IIb, a gene encoding an aminoglycoside-modifying enzyme, is under the positive control of surrogate regulator HpaA.

Antimicrobial agents and chemotherapy - 1 Dec 2003

Zeng Lin, Jin Shouguang

Abstract excerpt

Pseudomonas aeruginosa harbors a chromosomal aminoglycoside phosphotransferase gene, aph(3')-IIb, which confers P. aeruginosa resistance to several important aminoglycoside antibiotics, including kanamycin A and B, neomycin B and C, butirosin, and seldomycin F5. The aph(3')-IIb gene has been found to be regulated by an AraC-type transcriptional regulator (HpaA) encoded by a gene located upstream of the...

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Identifiers

PMID: 14638496
DOI: 10.1128/AAC.47.12.3867-3876.2003
PMCID: PMC296182

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Source receipt: pubmed, retrieved 7 Sept 2026.

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