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Article

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.

Science (New York, N.Y.) - 16 Apr 1999

Stebbins C E, Kaelin W G, Pavletich N P

Abstract excerpt

Mutation of the VHL tumor suppressor is associated with the inherited von Hippel-Lindau (VHL) cancer syndrome and the majority of kidney cancers. VHL binds the ElonginC-ElonginB complex and regulates levels of hypoxia-inducible proteins. The structure of the ternary complex at 2.7 angstrom resolution shows two interfaces, one between VHL and ElonginC and another between ElonginC and ElonginB. Tumorigenic...

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Source

Identifiers

PMID: 10205047
DOI: 10.1126/science.284.5413.455

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.PMID 10205047Read ↗

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VHL, the story of a tumour suppressor gene.Semantic proximity Read ↗

Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis.Semantic proximity Read ↗

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.Semantic proximity Read ↗

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