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Article

SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence

26 Jun 2010

Abstract excerpt

Members of the signal transducers and activators of transcription (STATs) family of proteins, which connect cytokine signaling to activation of transcription, are frequently activated in human cancers. Suppressors of cytokine signaling (SOCS) are transcriptional targets of activated STAT proteins that negatively control STAT signaling. SOCS1 expression is silenced in multiple human cancers suggesting a tumor...

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PMID: 20622265
DOI: 10.18632/aging.100163

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